Vertex Ventures US is an early-stage venture capital firm based in Palo Alto, California, focusing on investments in software infrastructure, developer tools, data, security, and vertical SaaS companies. As part of the global Vertex Ventures network, which includes affiliates in Israel, China, Southeast Asia, India, and Japan, the firm leverages a broad partner network to support portfolio companies.

Founded in 2015, Vertex Ventures US has invested in over 100 companies, with a portfolio that includes notable firms such as Cloudera, Evisort, and Couchbase. The firm emphasizes authentic partnerships with enterprising founders, aiming to drive change across B2B and enterprise technologies.