Lewis & Clark Ventures is an early-stage venture capital firm based in St. Louis, Missouri, founded by former founders and operators. They invest in late seed through Series B companies across the central U.S., focusing on sectors such as B2B software and healthcare.

The firm has made 35 investments, including notable companies like WaystoCap, nemedio, and Jiko. They prioritize building strong relationships with founders, valuing transparency and direct communication.